Fri Jul 15 2022

34 articles - From Friday Jul 08 2022 to Friday Jul 15 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Management and outcome of native joint septic arthritis: a nationwide survey in French rheumatology departments, 2016-2017.

Prognosis of NJSA remained severe with a high rate of morbimortality. Its management was very heterogeneous. This study highlights the importance of the new French recommendations, published after the completion of the study, in order to facilitate NJSA management.

Pubmed   Journal   ReadQx 

Pathogenic neuropsychiatric effect of stress-induced microglial interleukin 12/23 axis in systemic lupus erythematosus.

The microglial IL-12/23 axis in the mPFC might be associated with the pathogenesis and a promising therapeutic target for dNPSLE.

Pubmed   Journal   ReadQx 

Phase 3, multicentre, randomised, placebo-controlled study evaluating the efficacy and safety of ustekinumab in patients with systemic lupus erythematosus.

Ustekinumab did not demonstrate superiority over placebo in this population of adults with active SLE; adverse events were consistent with the known safety profile of ustekinumab.

Pubmed   Journal   ReadQx 

Tumour necrosis factor inhibitor use during pregnancy is associated with increased birth weight of rheumatoid arthritis patients' offspring.

This is the first study to show that TNFi use during pregnancy is associated with increased birth weight of offspring of women with well-controlled RA. The underlying mechanism of TNF-inhibition on birth weight and the long-term consequences for the offspring should be explored in future research.

Pubmed   Journal   ReadQx 

Arthritis Res Ther

Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients.

CG is frequent in SLE, but mostly asymptomatic. CryoVas features involve mostly joints, skin, and general symptoms. CryoVas in SLE appears to be a specific condition, with a low prevalence of neuropathy, membranoproliferative glomerulonephritis, and severe manifestations.

Pubmed   Journal   ReadQx 

Increased Wnt/ß-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis.

Dietary magnesium deficiency contributes to OA development, which is mediated by reduced autophagy through Wnt/ß-catenin signaling activation. These findings indicated potential benefits of adequate dietary magnesium for OA patients or those individuals at high risk of OA.

Pubmed   Journal   ReadQx   PMC

Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis.

We demonstrate a novel, powerful method which harnesses gene interaction networks for leveraging biologically relevant gene-gene interactions leading to improved models for predicting treatment response.

Pubmed   Journal   ReadQx 

The role of LCN2 and LCN2-MMP9 in spondylitis radiographic development: gender and HLA-B27 status differences.

L and LM are informative biomarkers for SIJ and spinal inflammation, as well as for ankylosing development in r-axSpA patients. Distinctive L+LM+ or L+ patterns not only could distinguish clinically aggressive vs milder course of disease, respectively, but also provide an explanation for B27-positive male patients being the most susceptible to severe ankylosis.

Pubmed   Journal   ReadQx   PMC

Arthritis Rheumatol

Assessing the immune cell subset and genetic mutations in palindromic rheumatism negative for rheumatoid factor and anti-citrullinated antibodies.

In seronegative PR patients, we identified a distinct CD14+CD11b+CD36+ subset, which can induce inflammatory response under stress and exert anti-inflammatory effects after phagocytosis of apoptotic cells, and a CD4+CD25-CD69+ T cell subset with pro- and anti-inflammation properties. Individuals harboring genetic mutations involving epigenetic modification, potentiation and resolution of stress-induced inflammation/ apoptosis, and dysregulated ER stress response could be predisposed to seronegative PR.

Pubmed   Journal   ReadQx 

Both disease activity and HLA-B27 determine gut microbiome dysbiosis in spondyloarthritis.

These findings reveal that genetic background, as well as the disease activity level, are likely to influence gut microbiota composition. It could be relevant for further research on chronic arthritis to focus on these key parameters.

Pubmed   Journal   ReadQx 

Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites.

In particular, the combination of leukotriene B4 and glycoursodeoxycholic acid sulfate were sensitive and specific predictors of PsA progression CONCLUSION: We observed notable differences in bile acid, purine, lipid, and amino acid-derived metabolites, among the HC, Ps and PsA patients and identified changes during the transition from Ps to PsA. The decreased bile acid, butyrate and elevated guanine levels in Ps patients at risk for PsA were particularly striking and may reflect gut microbial dysbiosis and dysregulated hepatic metabolism leading to altered proliferation of immune cells and enhanced cytokine expression.

Pubmed   Journal   ReadQx 

PI3 kinase delta deficiency protects from anti-myeloperoxidase vasculitis.

Mice with an inactive phosphoinositide 3-kinase delta are protected from anti-myeloperoxidase vasculitis. This is due to cell intrinsic defect in the recruitment of monocytes to the kidney. The results suggest that phosphoinositide 3-kinase delta is a potential therapeutic target in anti-neutrophil cytoplasmic antibody vasculitis.

Pubmed   Journal   ReadQx 

Safety and Efficacy of Bimekizumab in Patients with Active Psoriatic Arthritis: 3-Year Results from a Phase 2b Randomized Controlled Trial and its Open-Label Extension Study.

The safety profile of bimekizumab was consistent with previous reports, with no new safety signals identified. Sustained joint and efficacy responses were observed over three years.

Pubmed   Journal   ReadQx 

Smartphone-Assisted Patient-Initiated Care Versus Usual care in Patients With Rheumatoid Arthritis and Low Disease Activity: a Randomized Controlled Trial.

Patient-initiated care supported with smartphone self-monitoring was non-inferior to usual care in terms of DAS28 and led to a 38% reduction in rheumatologist consultations in RA patients with stable low disease activity.

Pubmed   Journal   ReadQx 

Telomere length and development of systemic lupus erythematosus: a Mendelian randomization study.

In contrast with previous observational studies, MR analyses found that longer TL is significantly associated with increased risk of SLE.

Pubmed   Journal   ReadQx 

Rheumatology (Oxford)

Basic calcium phosphate crystals induce the expression of extracellular matrix remodelling enzymes in tenocytes.

BCP crystals induce extracellular matrix remodelling enzymes, but not inflammatory cytokines, in tenocytes.

Pubmed   Journal   ReadQx 

Characteristics and Outcomes of a Hispanic Lupus Nephritis Cohort from Mexico.

Although the response to treatment and patient survival in this Latin American cohort is comparable to that observed in other regions, there is still a high rate of renal relapses and progression to decline in kidney function.

Pubmed   Journal   ReadQx 

Disease-specific expansion of CD29+IL-17RA+ T effector cells possessing multiple signaling pathways in spondyloarthritis.

CD29+IL-17RA+ T effector cells with enhanced Syk, NF-B, and JAK-STAT pathways was specifically increased in SpA and was correlated with disease activity, implicating a role of this newly identified T cell population in the pathogenesis. Anti-IL-17 monoclonal antibodies may be effective for patients by reducing this pathogenic T cell population.

Pubmed   Journal   ReadQx 

Examination of nailfold videocapillaroscopy findings in ANCA-associated vasculitis.

In AAV patients, NVC abnormalities are significantly associated with disease severity. This result suggests that NVC is a useful tool for assessing the disease activity and treatment response in AAV.

Pubmed   Journal   ReadQx 

Risankizumab improved health-related quality of life, fatigue, pain, and work productivity in psoriatic arthritis: Results of KEEPsAKE 1.

Risankizumab treatment resulted in greater improvements in HRQoL, fatigue, pain, and work productivity in patients with active PsA who have csDMARD-IR, when compared with placebo.

Pubmed   Journal   ReadQx 

Serum cholesterol loading capacity on macrophages is regulated by seropositivity and C-reactive protein in rheumatoid arthritis patients.

Oxidized LDL can directly influence CLC in dual seropositive RA patients. Two additional and independent pathways-via anti-oxLDL IgG and PCSK9-may mediate the effects of oxPL-apoB100 on CLC depending on CRP and seropositivity status. If externally validated, these findings may have clinical implications for cardiovascular risk prevention.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Arthritis Rheumatol

Concepts of entheseal pain.

e. pain and the structural findings in imaging in entheseal disease.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Ann Rheum Dis

Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease' by Wallace et al.

Pubmed   Journal   ReadQx 

Correspondence on "Safety of vaccination against SARS-CoV-2 in people with rheumatic and musculoskeletal diseases: results from the EULAR Coronavirus Vaccine (COVAX) physician-reported registry" by Machado et al.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

Optimal bridging strategy in active early rheumatoid arthritis: A bridge falling short ?

Pubmed   Journal   ReadQx 

Reply to the letter: Optimal bridging strategy in active early rheumatoid arthritis: A bridge falling short?

Pubmed   Journal   ReadQx 

SARS-CoV-2 immune responses in B cell depleted patients with autoimmune disease.

Pubmed   Journal   ReadQx 

Systemic glucocorticoids confound SARS-CoV-2 acquisition or even clinical outcomes in autoimmune disease patients treated with biologics.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

EULAR 75-year anniversary: commentaries on ARD papers from 50 years ago.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

Safety and Efficacy of Bimekizumab in Patients with Active Ankylosing Spondylitis: 3-Year Results from a Phase 2b Randomized Controlled Trial and its Open-Label Extension Study.

Pubmed   Journal   ReadQx 

Rheumatology (Oxford)

ADVERSE EVENTS OF TREATMENT WITH RITUXIMAB IN PATIENTS WITH MYOSITIS.

Pubmed   Journal   ReadQx 

Effective and safe treatment of anti-CD38 therapy in systemic lupus erythematosus associated refractory cerebral vasculitis induces immune tolerance.

Pubmed   Journal   ReadQx 

Influence of HLA polymorphisms on clinical features of VEXAS syndrome: a potential epistatic mechanism.

Pubmed   Journal   ReadQx 

Upadacitinib response rates in patients with psoriatic arthritis enrolled in the SELECT-PsA-1 and SELECT-PsA-2 trials assessed according to modified PsARC.

Pubmed   Journal   ReadQx