34 articles - From Friday Jul 08 2022 to Friday Jul 15 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Management and outcome of native joint septic arthritis: a nationwide survey in French rheumatology departments, 2016-2017. Prognosis of NJSA remained severe with a high rate of morbimortality. Its management was very heterogeneous. This study highlights the importance of the new French recommendations, published after the completion of the study, in order to facilitate NJSA management. |
Phase 3, multicentre, randomised, placebo-controlled study evaluating the efficacy and safety of ustekinumab in patients with systemic lupus erythematosus. Ustekinumab did not demonstrate superiority over placebo in this population of adults with active SLE; adverse events were consistent with the known safety profile of ustekinumab. |
Tumour necrosis factor inhibitor use during pregnancy is associated with increased birth weight of rheumatoid arthritis patients' offspring. This is the first study to show that TNFi use during pregnancy is associated with increased birth weight of offspring of women with well-controlled RA. The underlying mechanism of TNF-inhibition on birth weight and the long-term consequences for the offspring should be explored in future research. |
| Arthritis Res Ther |
Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients. CG is frequent in SLE, but mostly asymptomatic. CryoVas features involve mostly joints, skin, and general symptoms. CryoVas in SLE appears to be a specific condition, with a low prevalence of neuropathy, membranoproliferative glomerulonephritis, and severe manifestations. |
Increased Wnt/ß-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis. Dietary magnesium deficiency contributes to OA development, which is mediated by reduced autophagy through Wnt/ß-catenin signaling activation. These findings indicated potential benefits of adequate dietary magnesium for OA patients or those individuals at high risk of OA. |
Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis. We demonstrate a novel, powerful method which harnesses gene interaction networks for leveraging biologically relevant gene-gene interactions leading to improved models for predicting treatment response. |
The role of LCN2 and LCN2-MMP9 in spondylitis radiographic development: gender and HLA-B27 status differences. L and LM are informative biomarkers for SIJ and spinal inflammation, as well as for ankylosing development in r-axSpA patients. Distinctive L+LM+ or L+ patterns not only could distinguish clinically aggressive vs milder course of disease, respectively, but also provide an explanation for B27-positive male patients being the most susceptible to severe ankylosis. |
| Arthritis Rheumatol |
Assessing the immune cell subset and genetic mutations in palindromic rheumatism negative for rheumatoid factor and anti-citrullinated antibodies. In seronegative PR patients, we identified a distinct CD14+CD11b+CD36+ subset, which can induce inflammatory response under stress and exert anti-inflammatory effects after phagocytosis of apoptotic cells, and a CD4+CD25-CD69+ T cell subset with pro- and anti-inflammation properties. Individuals harboring genetic mutations involving epigenetic modification, potentiation and resolution of stress-induced inflammation/ apoptosis, and dysregulated ER stress response could be predisposed to seronegative PR. |
Both disease activity and HLA-B27 determine gut microbiome dysbiosis in spondyloarthritis. These findings reveal that genetic background, as well as the disease activity level, are likely to influence gut microbiota composition. It could be relevant for further research on chronic arthritis to focus on these key parameters. |
Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites. In particular, the combination of leukotriene B4 and glycoursodeoxycholic acid sulfate were sensitive and specific predictors of PsA progression CONCLUSION: We observed notable differences in bile acid, purine, lipid, and amino acid-derived metabolites, among the HC, Ps and PsA patients and identified changes during the transition from Ps to PsA. The decreased bile acid, butyrate and elevated guanine levels in Ps patients at risk for PsA were particularly striking and may reflect gut microbial dysbiosis and dysregulated hepatic metabolism leading to altered proliferation of immune cells and enhanced cytokine expression. |
PI3 kinase delta deficiency protects from anti-myeloperoxidase vasculitis. Mice with an inactive phosphoinositide 3-kinase delta are protected from anti-myeloperoxidase vasculitis. This is due to cell intrinsic defect in the recruitment of monocytes to the kidney. The results suggest that phosphoinositide 3-kinase delta is a potential therapeutic target in anti-neutrophil cytoplasmic antibody vasculitis. |
Safety and Efficacy of Bimekizumab in Patients with Active Psoriatic Arthritis: 3-Year Results from a Phase 2b Randomized Controlled Trial and its Open-Label Extension Study. The safety profile of bimekizumab was consistent with previous reports, with no new safety signals identified. Sustained joint and efficacy responses were observed over three years. |
Smartphone-Assisted Patient-Initiated Care Versus Usual care in Patients With Rheumatoid Arthritis and Low Disease Activity: a Randomized Controlled Trial. Patient-initiated care supported with smartphone self-monitoring was non-inferior to usual care in terms of |
| Rheumatology (Oxford) |
Characteristics and Outcomes of a Hispanic Lupus Nephritis Cohort from Mexico. Although the response to treatment and patient survival in this Latin American cohort is comparable to that observed in other regions, there is still a high rate of renal relapses and progression to decline in kidney function. |
Disease-specific expansion of CD29+IL-17RA+ T effector cells possessing multiple signaling pathways in spondyloarthritis. CD29+IL-17RA+ T effector cells with enhanced Syk, NF- |
Examination of nailfold videocapillaroscopy findings in ANCA-associated vasculitis. In AAV patients, NVC abnormalities are significantly associated with disease severity. This result suggests that NVC is a useful tool for assessing the disease activity and treatment response in AAV. |
Risankizumab improved health-related quality of life, fatigue, pain, and work productivity in psoriatic arthritis: Results of KEEPsAKE 1. Risankizumab treatment resulted in greater improvements in HRQoL, fatigue, pain, and work productivity in patients with active PsA who have csDMARD-IR, when compared with placebo. |
Serum cholesterol loading capacity on macrophages is regulated by seropositivity and C-reactive protein in rheumatoid arthritis patients. Oxidized LDL can directly influence CLC in dual seropositive RA patients. Two additional and independent pathways-via anti-oxLDL IgG and PCSK9-may mediate the effects of oxPL-apoB100 on CLC depending on CRP and seropositivity status. If externally validated, these findings may have clinical implications for cardiovascular risk prevention. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Rheumatol |
Letters to the editors and authors’ replies
| Ann Rheum Dis |
| Arthritis Rheumatol |
all remaining publications eg case reports, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |